The series follows the voyages of the Starfleet starship USS Enterprise (NCC-1701), captained by Christopher Pike, during its second five-year mission (2259-2264), which precedes Captain James T. Kirk's five-year mission narrated in the television series Star Trek. The series picks up on stardate 1738.12 (2259), a couple of years after the events that occurred in the second season of the television series Star Trek: Discovery, when Pike temporarily captained the USS Discovery.

In season two, the crew of the U.S.S. Enterprise, under the command of Captain Christopher Pike, confronts increasingly dangerous stakes, explores uncharted territories and encounters new life and civilizations. The crew will also embark on personal journeys that will continue to test their resolve and redefine their destinies. Facing friends and enemies both new and familiar, their adventures will unfold in surprising ways never seen before.

In season three, when we reconnect with the crew of the U.S.S. Enterprise, still under the command of Captain Pike, they face the conclusion of season two's harrowing encounter with the Gorn. But new life and civilizations await, including a villain that will test our characters' grit and resolve. An exciting twist on classic Star Trek, season three takes characters both new and beloved to new heights, and dives into thrilling adventures of faith, duty, romance, comedy and mystery, with varying genres never before seen on any other Star Trek.

In the fourth season, the crew of the U.S.S. Enterprise—led by Captain Christopher Pike—embarks on a series of thrilling and emotional adventures across the stars. As they journey to strange new worlds, they battle inner demons and external threats, encounter colorful new characters, reunite with familiar faces and confront terrifying aliens. Through it all, they strive to embrace a bright, hopeful future.