Lopez Tonight - Season 2
1 - Janet Jackson
Air Date: November 8, 2010
2 - Donald Elson, Kosta Trouva
Air Date: November 9, 2010
3 - Howie Mandel, Juliette Lewis
Air Date: November 10, 2010
4 - Denzel Washington, Hilary Duff
Air Date: November 11, 2010
5 - Tom Felton, Ne-Yo
Air Date: November 22, 2010
6 - David Arquette, Ashley Greene, Billy the Exterminator
Air Date: November 24, 2010
7 - Billy Bob Thornton, Kunal Nayyar, Ice Cube
Air Date: November 25, 2010
8 - Dwayne Johnson, Katie Cassidy
Air Date: November 25, 2010
9 - Jennifer Love Hewitt
Air Date: January 27, 2011
10 - Bill Cosby, Angela Kinsey, Atomic Tom
Air Date: November 30, 2010
11 - Charles Barkley, Brandy, Cee-Lo Green
Air Date: December 1, 2010
12 - Mario Lopez
Air Date: December 2, 2010
13 - Khloe Kardashian, Jo Frost, Nicki Minaj
Air Date: December 6, 2010
14 - Bob Saget, Nene Leakes, Keri Hilson
Air Date: December 7, 2010
15 - Alan Cumming, Chris D'Elia
Air Date: December 8, 2010
16 - Steve Harvey, the 88
Air Date: December 9, 2010
17 - Eric Stonestreet, J.B. Smoove, Dov Davidoff
Air Date: December 13, 2010
18 - Anna Faris, Apolo Anton Ohno, Natasha Bedingfield
Air Date: December 14, 2010
19 - Mila Kunis, Dr. Drew Pinsky, Chrisette Michele
Air Date: December 15, 2010
20 - Justin Timberlake, Stephen Dorff, Ciara
Air Date: December 16, 2010
21 - Xzibit, a performance from Cirque Du Soleil's "Mystere"
Air Date: December 20, 2010
22 - Gene Simmons, Scott Bakula, Bettye Lavette with the Ese Vatos
Air Date: December 21, 2010
23 - Ron Artest, will.i.am, Dean Cole
Air Date: December 22, 2010
24 - Jack Black, Hailee Steinfeld, Filter
Air Date: December 23, 2010
25 - Lauren Graham, Will Sasso, Plain White T's
Air Date: January 10, 2011
26 - Mary Lynn Rajskub, Maz Jobrani
Air Date: January 11, 2011
27 - El Debarge featuring Faith Evans, Michael Bearden & the Ese Vatos
Air Date: January 12, 2011
28 - David Duchovny, Kristen Schaal, Saving Abel
Air Date: January 13, 2011
29 - Seth Rogen, Ginnifer Goodwin, Sick Puppies
Air Date: January 17, 2011
30 - William H. Macy, Camille Grammer, Cali Swag District
Air Date: January 18, 2011
31 - Cameron Diaz, Jason Priestley, Luke Perry, Greg Fizsimmons
Air Date: January 19, 2011
32 - Bill Engvall, Johnny Weir, My Chemical Romance
Air Date: January 20, 2011
33 - Ashley Tisdale, Kevin Hart, Grace Potter & the Nocturnals
Air Date: January 24, 2011
34 - Vanessa Williams, Shorty Rossi
Air Date: January 25, 2011
35 - Jason Statham, Busy Philipps, Wiz Khalifa
Air Date: January 26, 2011
36 - Jennifer Love Hewitt, Guy Fieri
Air Date: January 27, 2011
37 - Kristen Bell, Jake Johnson, Slash
Air Date: January 31, 2011
38 - DeSean Jackson, the Thermals
Air Date: February 1, 2011
39 - Mindy Kaling, Derek Fisher, Jasper Redd, Arturo Sandoval
Air Date: February 2, 2011
40 - Billy Gardell, Rachel Bilson, OK Go
Air Date: February 3, 2011
41 - Jamie Foxx, Aubrey Plaza
Air Date: February 7, 2011
42 - Channing Tatum, Margaret Cho, 50 Cent with Governor
Air Date: February 8, 2011
43 - Joan Rivers, Greg Jennings, Baron Vaughn
Air Date: February 9, 2011
44 - Brad Womack, Taylor Momsen, the Pretty Reckless
Air Date: February 10, 2011
45 - R. Kelly, Paul Wesley, James Loney, Bobby Castillo, Tommy Davis, Kenny Landreaux, Rudy Law, Steve Lyons, Don Mattingly
Air Date: February 14, 2011
46 - Justin Bieber, Far East Movement
Air Date: February 15, 2011
47 - Liam Neeson, a performance by the Broadway cast of "Rock of Ages"
Air Date: February 16, 2011
48 - 200th Episode - Jenni "JWoww" Farley, Jim Jefferies
Air Date: February 17, 2011
49 - Amar'e Stoudemire, Kate Gosselin, Sebastian Maniscaclo
Air Date: February 21, 2011
50 - Martin Lawrence, Jared Leto, 30 Seconds to Mars
Air Date: February 22, 2011
51 - Forest Whitaker, Jessica Lucas, Bobby V & Bobby Brown
Air Date: February 23, 2011
52 - Jason Biggs, Anne Heche
Air Date: February 24, 2011
53 - Owen Wilson, Aly Michalka, Terry Fator
Air Date: February 28, 2011
54 - Cheryl Burke, Brandon T. Jackson, John Popper & the Duskray Troubadours
Air Date: March 1, 2011
55 - Ron Artest, DJ Pauly D, Michelle Rodriguez, Future Funk
Air Date: March 2, 2011
56 - Topher Grace, Scott Disick, Cake
Air Date: March 3, 2011
57 - Forest Whitaker, Donald Glover, Steel Train
Air Date: March 7, 2011
58 - Aaron Eckhart, Malin Akerman, Eric Andre
Air Date: March 8, 2011
59 - Curtis Stone, Lupe Fiasco
Air Date: March 9, 2011
60 - Pee-wee Herman, Emanuelle Chriqui
Air Date: March 10, 2011
61 - Mike Tyson, Emmy Rossum, 30 Seconds to Mars
Air Date: March 21, 2011
62 - Jim Rome, Boney James
Air Date: March 22, 2011
63 - Matthew McConaughey, Micky Ward, Ron Artest featuring George Lopez, Fat Joe, B Real, Lenny and Max from Aventura and Taz
Air Date: March 23, 2011
65 - Bethenny Frankel, D.L. Hughley, Seether
Air Date: March 28, 2011
66 - Vanessa Hudgens, Sergio Mendes
Air Date: March 29, 2011
67 - Larry King, Brent Weinbach
Air Date: March 30, 2011
68 - Snoop Dogg, Brittany Snow
Air Date: March 31, 2011
69 - Lil Jon, Panic! At The Disco
Air Date: April 4, 2011
70 - Drew Carey, Sarah Shahi, Quinn Dahle
Air Date: April 5, 2011
71 - Lisa Lampanelli
Air Date: April 6, 2011
72 - Danny McBride, Camilla Luddington, Avril Lavigne
Air Date: April 7, 2011
124 - Kathy Griffin, Tom Felton
Air Date: August 2, 2011