The first season of Nip/Tuck premiered on July 23, 2003 and concluded on October 21, 2003. It consisted of 13 episodes.

The second season of Nip/Tuck premiered on June 22, 2004 and concluded on October 5, 2004. It consisted of 16 episodes.

The third season of Nip/Tuck premiered on September 20, 2005 and concluded on December 20, 2005. It consisted of 15 episodes.

The fourth season of Nip/Tuck premiered on September 9, 2006 and concluded on December 12, 2006. It consisted of 15 episodes.

The fifth season of Nip/Tuck premiered on October 30, 2007 and concluded on March 3, 2009. The unusually lengthy interval, for an American series, was a direct result of the 2007–2008 Writers Guild of America strike. The season consisted of 22 episodes.