1 - La fragilidad del reino

Columbus' voyage is a success but a storm forces him to land on Portugal. The royals travel to Barcelona to sign a treaty with France, who ambitions to conquer Naples. The queen meets her new confessor, and her daughter ponders her future.

2 - Gobernar con mano dura

Columbus hides his doubts as he is pressed to make a second voyage. Portugal disputes the new lands to Castile, and France invades Italy. In Rome, the Pope juggles the rival countries interests for his own benefit.

3 - Nacidos para gobernar

4 - Atracción fatal

5 - El drama llega a la corte

6 - Reina de toda la península

7 - Muere la Príncesa de Asturias

8 - A Isabel le supera la tragedia

9 - Felipe y Juana llegan a sus reinos

10 - Isabel y Fernando o Juana y Felipe

11 - La llamaban Juana 'La loca'

12 - ¿Conservarán el legado de Isabel?

13 - La muerte de Isabel