The Daily Life Arc is the first story arc of the Katekyo Hitman Reborn!. It centers around the life of Tsunayoshi Sawada, and the antics caused by his infant home tutor, Reborn, who trains him to become the Tenth Generation Boss of the Vongola Famiglia. The Kokuyo Arc is the second story arc of the Katekyo Hitman Reborn! series. It follows Tsuna and his Family's attempt at saving Futa and stop the Kokuyo Junior High Gang.

The Varia Arc details Tsuna and his Guardians fighting for the ownership of the Vongola Rings, which are used to prove the true successors to the Vongola Famiglia.

The Future Arc focuses on Tsuna and his Family travelling 9 years and 10 months into the future by Lambo's Ten Year Bazooka in order to confront the Millefiore Famiglia and change the future.

The Arcobaleno Trials Arc is an anime-exclusive arc that occurs when Tsuna and his Family traveled back to the past to obtain the Arcobaleno Seals and unlock the true power of the Vongola Rings. The story was supervised by Akira Amano.

The Choice Arc takes place after Tsuna and the rest of his family acquire the Arcobaleno Seals, and travel back into the future to confront Byakuran and the remaining Millefiore Famiglia.

The Primo Family Arc is an anime-exclusive arc that details the happenings when Tsuna and his Family that went to the future travel back to the past (except Basil) to get stronger with the help of the Arcobaleno and obtain the Vongola's true power.

The Future Final Battle Arc takes place right after Choice, when the Vongola Famiglia loses and escapes in order to protect Uni. The final battles are about the Vongola members fighting to stop the Real Six Funeral Wreaths from taking Uni to Byakuran.